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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク WW domain ： ウィキペディア英語版 WW domain The WW domain,〔 (also known as the rsp5-domain〔 or WWP repeating motif〔) is a modular protein domain that mediates specific interactions with protein ligands. This domain is found in a number of unrelated signaling and structural proteins and may be repeated up to four times in some proteins.〔〔〔〔 Apart from binding preferentially to proteins that are proline-rich, with particular proline-motifs, ()-P-P-()-Y, some WW domains bind to phosphoserine- phosphothreonine-containing motifs.〔 == Structure and ligands == The WW domain is one of the smallest protein modules, composed of only 40 amino acids, which mediates specific protein-protein interactions with short proline-rich or proline-containing motifs.〔 Named after the presence of two conserved tryptophans (W), which are spaced 20-22 amino acids apart within the sequence,〔 the WW domain folds into a meandering triple-stranded beta sheet.〔 The identification of the WW domain was facilitated by the analysis of two splice isoforms of YAP gene product, named YAP1-1 and YAP1-2, which differed by the presence of an extra 38 amino acids. These extra amino acids are encoded by a spliced-in exon and represent the second WW domain in YAP1-2 isoform.〔〔 The first structure of the WW domain was determined in solution by NMR approach.〔 It represented the WW domain of human YAP in complex with peptide ligand containing Proline-Proline-x–Tyrosine (PPxY where x = any amino acid) consensus motif.〔〔 Recently, the YAP WW domain structure in complex with SMAD-derived, PPxY motif-containing peptide was further refined.〔 Apart from the PPxY motif, certain WW domains recognize LPxY motif (where L is Leucine),〔 and several WW domains bind to phospho-Serine-Proline (p-SP) or phospho-Threonine-Proline (p-ST) motifs in a phospho-dependent manner.〔 Structures of these WW domain complexes confirmed molecular details of phosphorylation-regulated interactions.〔〔 There are also WW domains that interact with polyprolines that are flanked by arginine residues or interrupted by leucine residues, but they do not contain aromatic amino acids.〔〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「WW domain」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.